Archaeabacteria bipolar lipid analogues: structure, synthesis and lyotropic properties

Over the past several years, various archaeal symmetrical/unsymmetrical and acyclic/macrocyclic bipolar lipid analogues have been synthesized to study, from well-defined molecules, the membrane organizing and packing properties of this new class of amphiphiles. This review focuses on the structure and the synthesis of selected bolaamphiphiles and describes their supramolecular self-assembling properties in aqueous media.