Author/Authors :
Mirdamadi، Ahmad نويسنده Assistant Professor, Department of Cardiology, School of Medicine, Najaf Abad Branch, Islamic Azad University, Isfahan, Ir , , Farzamnia، Hamid نويسنده Resident, Cardiac Rehabilitation Research Center, Isfahan Cardiovascular Research Institute, Department of Cardiology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran , , Varzandeh، Pooyan نويسنده MD, School of Medicine, Najaf Abad Branch, Islamic Azad University, Isfahan, Iran , , Almasi، Naser نويسنده PhD, Laboratory Sciences, School of Medicine, Najaf Abad Branch, Islamic Azad University, Isfahan, Iran , , Arasteh، Mahfar نويسنده MD, School of Medicine, Najaf Abad Branch, Islamic Azad University, Isfahan, Iran ,
Abstract :
BACKGROUND: The role of novel biomarkers like homocystein as a risk factor of coronary
artery disease (CAD) is being increasingly recognized. Since there is a marked geographical
variation in plasma homocystein concentration and because of importance of
hyperhomocysteinemia as a CAD risk factor and due to the paucity of studies in Iran evaluating
this risk factor in our population, we evaluated the association between plasma total
homocysteine (tHcy) concentration and CAD risk in Iranian population.
METHODS: In a case-control study, we compared the level of tHcy of forty five patients of
angiographically proven CAD with forty five subjects without CAD as control group matched for
age and gender. The patients with diabetes, hypertension, thyroid dysfunction, chronic renal
failure, hyperlipidemia and obesity and other conventional CAD risk factors were excluded from
the study. Plasma tHcy was measured using immunoturbidimetry. The results were compared
between groups using student t test.
RESULTS: CAD patients had significantly higher mean plasma tHcy than control group
(17.1±5.3 versus 14.2±3.8, P= 0.004).
CONCLUSION: This study denoted that high plasma homocysteine concentration was
associated to CAD risk in Iranian people.
