Author/Authors :
Rogha، Mehran نويسنده MD, Assistant Professor, Department of Internal Medicine, School of Medicine, Islamic Azad University, Najafabad Branch, Isfahan , , Dadkhah، Davood نويسنده Assistant Researcher, Department of Internal Medicine, Najafabad Branch, Islamic Azad University, Isfahan, Iran , , Pourmoghaddas، Zahra نويسنده MD, General Practitioner, Department of Internal Medicine, School of Medicine, Islamic Azad University, Najafabad Branch, Isfahan , , Shirneshan، Keivan نويسنده Pathologist, Isfahan Shariati Hospital, Isfahan, Iran , , Nikvarz، Marjan نويسنده Assistant Researcher, Department of Internal Medicine, Najafabad Branch, Islamic Azad University, Isfahan, Iran , , Pourmoghaddas، Masoud نويسنده MD, Professor of Interventional Cardiology, Chamran Heart Hospital, Isfahan University of Medical Sciences, Isfahan ,
Abstract :
BACKGROUND: There are few literatures evaluating the association between cytotoxinassociated
gene A (CagA) positive strains of Helicobacter pylori (HP) and the severity of
coronary heart disease (CHD). This study was designed to investigate this association.
METHODS: Medical and drug history of 112 consecutive patients who were candidate for
coronary angiography were taken. Fasting blood samples were obtained to measure C-reactive
protein (CRP), anti Helicobacter pylori immunoglobulin G (anti-HP IgG), anti-CagA antibody
(Ab) and interlukine-6 (IL6). According to angiography reports, participants were divided into
patients with mild (n = 69) and with sever CHD (n = 36). To measure the association between
CagA positive strains of HP with the severity of CHD, multivariate logistic regression tests were
used by adjusting age, sex, history of diabetes mellitus (DM), dyslipidemia (DLP), and/or
hypertension (HTN), CRP status and IL-6 level.
RESULTS: The analysis was concluded on 105 subjects. HP infection and CagA Ab were not
significantly higher compared to the patients with severe and mild CHD (P = 0.28 and P = 0.68,
respectively). Colonization of CagA positive HP did not significantly associate with severity of
CHD (OR 1.05, 95% CI 0.33-3. 39).
CONCLUSION: Colonization of CagA positive HP was not an independent risk factor for severe
coronary heart disease.
