Author/Authors :
Deshmukh، Surekha N نويسنده Department of Chemistry, Dr. Babasaheb Ambedkar Marathwada University, Aurangabad - 431004, Maharashtra, India. , , Gujar، Jitendra B نويسنده Department of Chemistry, Dr. Babasaheb Ambedkar Marathwada University, Aurangabad - 431004, Maharashtra, India. , , Mane، Ramrao A نويسنده Department of Chemistry, Dr. Babasaheb Ambedkar Marathwada University, Aurangabad - 431004, Maharashtra, India. , , Shingare، Murlidhar S نويسنده Department of Chemistry, Dr. Babasaheb Ambedkar Marathwada University, Aurangabad - 431004, Maharashtra, India. ,
Abstract :
A rapid and efficient one-pot, four-component protocol towards the synthesis of polyhydroquinoline derivatives has been developed. The condensation of aldehyde, dimedone, ethyl acetoacetate and ammonium acetate in presence of stannous chloride was carried out under solvent free condition to synthesize a variety of polyhydroquinoline derivatives in good to excellent yields. The present method provides several advantages such as mild reaction conditions, simple work-up procedure, short reaction time and high yields.
