Author/Authors :
Izadi، Morteza نويسنده , , Fazel، Mojgan نويسنده International Travel Medicine Center of Iran, Tehran, Iran , , Karbasi-Afshar، Reza نويسنده Cardiovascular Research Center; Baqiyatallah University of Medical Sciences; Tehran, Iran , , Saadat، Seyed-Hassan نويسنده , , Nasseri، Mohammad Hassan نويسنده Health Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran , , Jonaidi Jafari، Nematollah نويسنده Health Research Center, Baqiyatallah University of Medical Sciences, Tehran, IR Iran , , Ranjbar، Reza نويسنده Molecular Biology Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran , , Kazemi-Saleh، Davood نويسنده Health Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran ,
Abstract :
BACKGROUND: Diabetes mellitus (DM) is a very well-known risk factor for development of
atherosclerosis, and it has been hypothesized that poor glycemic control and hyperglycemia
plays a major role in this process. In the current study, we aimed to evaluate the associates of
poor glycemic control in Iranian patients who have already undergone coronary artery bypass
grafting (CABG), with especial focus on the inhabitation of infectious agents within the coronary
arterial wall.
METHODS: In January 2010, 52 consecutive patients with type 2 DM who undergone CABG at
the Department of Cardiovascular Surgery of Baqiyatallah University of Medical Sciences
(Tehran, Iran) were included into this cross-sectional study and biopsy specimens from their
coronary plaques were taken and analyzed by polymerase chain reaction (PCR) methods for
detecting Helicobacter species, cytomegalovirus (CMV) and Chlamydia pneumoniae, and their
potential relation to the glycemic control status in these patients.
RESULTS: Compared to that in diabetic patients with mean fasting blood sugar (FBS) levels FBS <
126, atherosclerotic lesions in type 2 diabetic patients with poor glycemic control (FBS > 126) were
significantly more likely to be positive for CMV PCR test (41% vs. 9%, respectively; P = 0.05). In
laboratorial test results, mean triglyceride level was significantly higher among patients of poor
glycemic control (168 ± 89 vs. 222 ± 125 mg/dl, respectively; P = 0.033). Hypertension was also
significantly more prevalent in this population (73% vs. 36%, respectively; P = 0.034).
CONCLUSION: Type 2 diabetic patients with poor glycemic control can be at higher risk for
developing CMV infection in their coronary arterial wall, which can promote atherosclerosis
formation process in this patient population. According to the findings of this study, we
recommend better control of serum glucose levels in type 2 diabetic patients to prevent
formation/progression of atherosclerosis.
