Author/Authors :
Zargari، Peyman نويسنده Department of Biology, Science and Research branch, Islamic Azad University, Tehran, Iran , , Ghasemi، Mohammad R. نويسنده Department of Medical Genetics, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran , , Pirhoushiaran، Maryam نويسنده Department of Medical Genetics, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran , , Vakili، Veda نويسنده Shiraz University of Medical Sciences, Shiraz , , Hami، Javad نويسنده Department of Anatomical sciences, School of Medicine, Birjand University of Medical Sciences, Birjand, Iran , , Farzadfard، Mohammad Taghi نويسنده Department of Neurology, Ghaem Hospital, Mashhad University of Medical Sciences, Mashhad, Iran , , Sasan nezhad، Payam نويسنده Department of Neurology, Ghaem medical Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran , , Azarpazhooh، Mahmood R. نويسنده Department of Neurology, Ghaem medical Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran , , Sadr-Nabavi، Ariane نويسنده Department of Human Genetics, Mashhad University of Medical Sciences, Mashhad, Iran Sadr-Nabavi, Ariane
Abstract :
Stroke is the leading cause of death and disability in the world after the cancer and cardiovascular diseases. Genetic
factors have main significance to got stroke. Renin-angiotensin system contains candidate genes and
polymorphisms for causing stroke. There are reported associations between stroke and angiotensin II type-1
receptor g. 1166A > C polymorphism (rs5186). Therefore in this study this association was investigated for the east
Iranian population. This study is based on 201 stroke patients and 220 controls. To predict the genetic risk of stroke
allele and genotype frequencies of angiotensin II type-1 receptor rs5186 were analyzed in this population according
to stroke subtypes, gender, age, hypertension, diabetes mellitus, high and low density lipoprotein and triglycerides.
According to statistical analysis no significant difference was found between case and control groups. But there
were a significant relevance between total cholesterol and stroke (p = 0.037). In this population angiotensin II type-
1 receptor g. 1166A > C polymorphism did not increase the risk of stroke. The main reason for this study is
complex nature of gene-environment interactions in the pathophysiology of this disease.
