Title of article
Smooth muscle relaxant activity of Crocus sativus (saffron) and its constituents: possible mechanisms
Author/Authors
-، - نويسنده Neurogenic Inflammation Research Centre and Dept. of Physiology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran Mokhtari-Zaer, Amin , -، - نويسنده Student Research Committee, Mashhad University of Medical Sciences, Mashhad, Iran Khazdair, Mohammad Reza , -، - نويسنده Neurogenic Inflammation Research Centre and Dept. of Physiology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran Boskabady, Mohammad Hossein
Issue Information
فصلنامه با شماره پیاپی 0 سال 2015
Pages
11
From page
365
To page
375
Abstract
-
Abstract
Saffron, Crocus sativus L. (C. sativus) is rich in carotenoids and used in traditional medicine for treatment of various conditions such as coughs, stomach disorders, amenorrhea, asthma and cardiovascular disorders. These therapeutic effects of the plant are suggested to be due to its relaxant effect on smooth muscles. The effect of C. sativus and its constituents on different smooth muscles and the underlying mechanisms have been studied. Several studies have shown the relaxant effects of C. sativus and its constituents including safranal, crocin, crocetin and kaempferol on blood vessels. In addition, it was reported that saffron stigma lowers systolic blood pressure. The present review highlights the relaxant effects of C. sativus and its constituents on various smooth muscles. The possible mechanisms of this relaxing effect including activation of ß2-adrenoceptors, inhibition of histamine H1 and muscarinic receptors and calcium channels and modulation of nitric oxide (NO) are also reviewed.
Journal title
Avicenna Journal of Phytomedicine AJP)
Serial Year
2015
Journal title
Avicenna Journal of Phytomedicine AJP)
Record number
2324347
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