Author/Authors :
Maghsoudi، Nader نويسنده , , ghasemi، Rasoul نويسنده Neuroscience Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran ghasemi, Rasoul , Ghaempanah، Zahra نويسنده Reproductive Biotechnology Research Center, Avicenna Research Institute, ACECR , , Motavalizadeh Ardekani، Ali نويسنده Reproductive Biotechnology Research Center, Avicenna Research Institute, ACECR, Tehran, Iran Motavalizadeh Ardekani, Ali , Nooshinfar، Elahe نويسنده Department of Physiology, Faculty of Paramedical Sciences, Shahid Beheshti University of Medical Sciences ,
Abstract :
Introduction: Brain-Derived Neurotrophic Factor (BDNF) and its receptor, TrkB, in the hippocampus are targets for adverse effects of stress paradigms; in addition, BDNF and its receptor play key role in the pathology of brain diseases like depression. In the present study, we evaluated the possible role of hippocampal BDNF in depression during pregnancy,
Methods: To achieve the purpose, repeated restrain stress (1 or 3 hours daily for 7 days) during the last week of pregnancy was used and alteration in the gene expression of hippocampal BDNF and TrkB evaluated by semi-quantitative PCR.
Results: The results showed that in stress group the level of ACTH and Corticosterone is increased showing that our model was efficient in inducing psychological stress; we also found that BDNF and TrkB expression are decreased in 3 hours stress group but not in 1 hour stress compared to control group.
Discussion: Our results imply that decrease in BDNF and its receptor could contribute in some adverse effects of stress during pregnancy such as elevation of depressive like behavior.
