Author/Authors :
Taghizadeh، Eskandar نويسنده MSc in Human Genetics, Genetics Department, Shahid Sadoughi University of Medical Sciences, Yazd, Iran. , , Kalantar، Seyed Mehdi نويسنده , , Mahdian، Reza نويسنده Department of Pediatrics, Kerman University of Medical Sciences, Kerman, Iran Mahdian, Reza , Sheikhha، Mohammad Hasan نويسنده , , Farashahi Yazd، Ehsan نويسنده Department of Genetics, Faculty of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran. , , Ghasemi-Esmailabad، Saeed نويسنده Department of Genetics, Shahid Sadoughi University of Medical Sciences, Yazd, Iran , , shahbazi، zahra نويسنده ,
Abstract :
Background: Sulfatase 1 (SULF1) function is to remove the 6-O-sulphate group from heparan sulfate. This action changes the binding sites of extracellular growth factors. SULF1 expression has been reported to be changed in angiogenesis. We hypothesized that single nucleotide polymorphisms (SNPs) of SULF1 would impact clinicopathologic characteristics. Objective: Study of SULF1 gene polymorphism with fetus failure in in vitro fertilization (IVF) technique. Materials and Methods: We studied one common (minor allele frequency > 0.05) regulatory SNP, rs6990375, with polymerase chain reaction and restriction fragment length polymorphism method, in 53 infertile women with fetus failure in IVF technique and 53 women with at least one healthy child as controls. Results: We found that rs6990375 is significantly associated with an early failure in IVF and frequency of G allele is high in women with fetus failure in IVF technique (p < 0.001). Conclusion: These findings suggest that SULF1genetic variations may play a role in IVF technique fetus failure. Further studies with large sample sizes on SULF1 SNPs may be useful in support of this claim.
