Title of article
Synthesis and Evaluation of Ethyl 2,4-dioxo-4-arylbutanoate Derivatives as Src Kinase Inhibitors
Author/Authors
Rafinejad، A. نويسنده 1 Department of Medicinal Chemistry, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Islamic Republic of Iran , , Fallah Tafti، A. نويسنده Department of Medicinal Chemistry, Faculty of Pharmacy, Tehran University of Medical sciences, Tehran, I.R.Iran. , , Tiwari، R. نويسنده 2 Department of Biomedical and Pharmaceutical Sciences, College of Pharmacy, University of Rhode Island, Kingston, RI 02881, USA , , Foroumadi، A. نويسنده Department of Medicinal Chemistry, Faculty of Pharmacy and Pharmaceutical Sciences Research Center, Tehran University of Medical Sciences, Tehran, I.R.Iran. , , Akbarzadeh، T. نويسنده ,
Issue Information
فصلنامه با شماره پیاپی 4 سال 2015
Pages
5
From page
321
To page
325
Abstract
In this work, different ethyl 2,4-dioxo-4-arylbutanoate derivatives were prepared and evaluated for their Src Kinase inhibitory activity. For this purpose, the appropriate substituted acetophenone derivatives reacted with diethyl oxalate in the presence of sodium ethoxide in dried ethanol to give the corresponding products. All compounds showed moderate activities comparing with staurosporine as the reference drug.
Journal title
Journal of Sciences
Serial Year
2015
Journal title
Journal of Sciences
Record number
2353603
Link To Document