New Homogeneous And Robust Catalyst for Heck and Suzuki Reactions

A novel and efficient palladium-based homogeneous catalyst was fabricated and used as a robust catalyst in Suzuki–Miyaura cross-coupling and Heck reactions. 2-Amino-N-(pyridin-2-ylmethyl)benzamide was introduced as a versatile ligand for palladium-catalyzed cross-coupling reactions. The desired active and stable homogeneous Pd catalyst was prepared via the coordination of Pd with 2-amino-N-(pyridin-2-ylmethyl)benzamide and fully characterized. The catalyst exhibited excellent activity in Suzuki–Miyaura cross-coupling and Heck reactions. The proposed protocol featured mild reaction conditions and efficiency using LiOH as base.