Studying Outbreak of Pain Relieving by Three Drugs Including Alfentanil, Magnesium Sulfate and Ketamine during Intravenous Injection of Propofol

Purpose: Propofol is one of the most common drugs used in anesthesia induction and the pain during its intravenous injection is one of the most important side effectsthat it has. Therefore, many methods and drugs have been examined so far to reduce or eliminate this side effect. In this study a lot the effects of Alfentanil, Magnesium Sulfate and Ketamine drugs on reducing the pain during intravenous injection of Propofol are investigated. Materials and Methods: This study was performed on 220 patients who underwent orthopedic surgeries in Poursina hospital in 2010. The intensity of Propofol intravenous injection pain is measured after using premedication by Visula Analogue Scale (VAS). The results are analyzed using Chi square and Post hoc tests. Results: According to the gathered data and analysis of variance statistic tests, we found that after Propofol injection there is a meaningful difference in quantity of VAS score among the studied groups (Chi square = 49.78 and df = 3 and P = .0001). According to Post hoc test the VAS score in Magnesium Sulfate group has a meaningful difference in comparison to other groups, while there is no meaningful difference among other groups (P = .05). Conclusion: Despite the reduction the Propofol intravenous injection pain in three studied drugs in this thesis, there is no preference among them.