Title of article
The effects of Nigella sativa on sickness behavior induced by lipopolysaccharide in male Wistar rats
Author/Authors
-، - نويسنده Neurocognitive Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran Norouzi, Fatemeh , -، - نويسنده Pharmacological Research Center of Medicinal Plants, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran Abareshi, Azam , -، - نويسنده Department of Physiology, School of Medicine, Jiroft University of medical Sciences, Jiroft, Iran Anaeigoudari, Akbar , -، - نويسنده Neurocognitive Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran Shafei, Mohammad Naser , -، - نويسنده Neurogenic Inflammation Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. Gholamnezhad, Zahra , -، - نويسنده Mashhad Technical Faculty, Technical and Vocational University, Mashhad, Iran Saeedjalali, Mohsen , -، - نويسنده Department of Physiology School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. Mohebati, Reza , -، - نويسنده Neurocognitive Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran Hosseini, Mahmoud
Issue Information
دوماهنامه با شماره پیاپی 0 سال 2016
Pages
13
From page
104
To page
116
Abstract
-
Abstract
Objective: Neuroimmune factors contribute on the pathogenesis of sickness behaviors. Nigella sativa (NS) has anti-inflammatory, anti-anxiety and anti-depressive effects. In the present study, the effect of NS hydro-alcoholic extract on sickness behavior induced by lipopolysaccharide (LPS) was investigated. Materials and Methods: The rats were divided into five groups (n=10 in each): (1) control (saline), (2) LPS (1 mg/kg, administered two hours before behavioral tests), (3-5) LPS-Nigella sativa 100 , 200 and 400 mg/kg (LPS-NS 100, LPS-NS 200 and LPS-NS 400, respectively). Open- field (OF), elevated plus maze (EPM) and forced swimming test (FST) were performed. Results: In OF, LPS reduced the peripheral crossing, peripheral distance, total crossing and total distance compared to control (pConclusion: The results of the present study showed that the hydro-alcoholic extract of NS reduced the LPS-induced sickness behaviors in rats. Further investigations are required for better understanding the responsible compound (s) and the underlying mechanism(s).
Journal title
Avicenna Journal of Phytomedicine AJP)
Serial Year
2016
Journal title
Avicenna Journal of Phytomedicine AJP)
Record number
2356674
Link To Document