Author/Authors :
Shahrani، Mehrdad نويسنده Medical Plants Research Center, Shahrekord University of
Medical Sciences, Shahrekord, IR Iran , , Asgari، Azam نويسنده Medical Plants Research Center, Shahr-e-kord University of Medical Sciences, Shahr-e-Kord, Iran Asgari, Azam , Abedi Gheshlaghi، Zahra نويسنده Nickan Research Institute, Isfahan, IR Iran , , Parvin، Neda نويسنده Medical Plants Research Center, Shahr-e-kord University of Medical Sciences, Shahr-e-Kord, Iran Parvin, Neda , Nasri، Parto نويسنده Department of Pathology, Isfahan University of Medical Sciences, Isfahan, IR Iran , , Shirzad، Hedayatollah نويسنده Department of Immonology, Medical Plants Research Center, Shahr-e-Kord University of Medical Sciences, Shahr-e-Kord, Iran Shirzad, Hedayatollah , Rafieian-kopaei، Mahmoud نويسنده Department of Pharmacology, Medical Plants Research Center, Shahr-e-kord University of Medical Sciences, Shahr-e-Kord, Iran Rafieian-kopaei, Mahmoud
Abstract :
Flavonoids are a group of polyphenolic compounds with antioxidant properties that help reduce cardiovascular risk factors. Kelussia odoratissima is a flavonoid-containing plant, the effect of which was analyzed on decreasing blood lipid levels in mice. The present study was carried out with the aim of determining the anti-hyperlipidemia effects of this herb on mice. In this preclinical study, 70 Balb/c mice were divided to five 14-member groups and received normal diet, normal diet containing 5% olive oil, high cholesterol (2% cholesterol and 5% olive oil) diet and high cholesterol diet accompanied by Kelussia odoratissima 10% or 20% hydro-alcoholic extract. After two weeks, blood samples were taken and cholesterol, triglyceride, low density lipoprotein (LDL), very low density lipoprotein (VLDL), high density lipoprotein (HDL), and fasting blood sugar (FBS) were measured. In this animal model, the levels of all serum lipids including cholesterol, HDL, VLDL, LDL, triglyceride and FBS had a significant decrease two weeks after the beginning of the study. Moreover, at the same time, in the group that received 20% hydro-alcoholic extract, the serum levels of cholesterol, HDL and LDL had a significant decrease (P < 0.05). Kelussia odoratissima might have a desirable effect on serum lipid profile and might have beneficial effects on hyperlipidemic patients
