Evaluation of the leishmanicidal and cytotoxic potential of essential oils derived from ten colombian plants.
Sanchez-Suarez، Jf نويسنده Immunotoxicology Research Group, Dept. of Pharmacy. Faculty of Sciences, Universidad Nacional de Colombia, Bogot?, Colombia. Sanchez-Suarez, Jf , Riveros، I نويسنده Green Andina LTDA, Bogot?, Colombia. Riveros, I , Delgado، G نويسنده Immunotoxicology Research Group, Dept. of Pharmacy. Faculty of Sciences, Universidad Nacional de Colombia, Bogot?, Colombia. Delgado, G
Background: The leishmanicidal and cytotoxic activity of ten essential oils obtained from ten plant specimens were evaluated.
Methods: Essential oils were obtained by the steam distillation of plant leaves without any prior processing. Cytotoxicity was tested on J774 macrophages and leishmanicidal activity was assessed against four species of Leishmania associated with cutaneous leishmaniasis.
Results: Seven essential oils exhibited activity against Leishmania parasites, five of which were toxic against J774 macrophages. Selectivity indices of >6 and 13 were calculated for the essential oils of Ocimum basilicum and Origanum vulgare, respectively.
Conclusion: The essential oil of Ocimum basilicum was active against promastigotes of Leishmania and innocuous to J774 macrophages at concentrations up to 1600 μg/mL and should be further investi-gated for leishmanicidal activity in others in vitro and in vivo experimental models.