Backgrund:Free-living amoebae belonging to the genus Acanthamoeba have an environmental distribution. Amoebic keratitis due to these protozoan parasites continue to rise in Iran and worldwide. In Iran, there are various researches regard-ing both morphological and molecular identification of Acanthamoeba spp. in envi-ronmental and clinical samples. However, there is no thorough review about Acan-thamoeba genotypes and their distribution in environmental sources such as water, dust and biofilm in Iran. Besides, according to increasing cases of Amoebic kerati-tis in the region awareness regarding the pathogenic potential of these sight-threatening amoebae is of utmost importance.
Methods:We conducted a thorough review based on the database sources such as MEDLINE, PubMed and Google scholar. No restrictions were placed on study date, study design or language of publication. We searched all valuable and relevant information considering the occurrence of the Acanthamoeba in both environmental and clinical samples.
Results:According to our thorough review Acanthamoeba belonging to T4 geno-type is the most prevalent type strain in environmental and clinical samples in sev-eral regions in Iran and worldwide, however, there are reports regarding Acan-thamoeba belonging to other genotypes such as T2, T3, T5, T6 and T11 and the mentioned point could leads us to more researches with the goal of presenting the real genotype dominance of Acanthamoeba and related disease in the country.
Conclusion:Overall, the present review will focus on present status of genotypes of Acanthamoeba in Iran during recent years.