Title of article
A Study on Genetic Association of Interleukin-16 Single Nucleotide Polymorphism (rs1131445) With Chronic Hepatitis B Virus Infection in Iranian Patients
Author/Authors
Behelgardi، Abbas نويسنده Gastroenterology and liver diseases Research center, Shahid Beheshti University of Medical Sciences, Tehran, . , , Hosseini ، Seyed Masoud نويسنده Department of Microbiology, Faculty of Biological Sciences, Shahid Beheshti University, Tehran, Iran Hosseini , Seyed Masoud , Mohebbi، Seyed Reza نويسنده Research Center for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran , , Azimzadeh، Pedram نويسنده Gastroenterology and Liver Diseases Research Center, Shahid Beheshti University of Medical Sciences, Tehran , , Derakhshani، Shaghayegh نويسنده Gastroenterology and Liver Diseases Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, IR Iran , , Karimi، Khatoon نويسنده Foodborne and Waterborne Diseases Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, IR Iran , , Sharifian، Afsaneh نويسنده , , Zali، Mohammad Reza نويسنده Department of Celiac Disease, Gastroenterology and Liver Diseases Research Center, Shahid Beheshti University of Medical Sciences, Tehran ,
Issue Information
فصلنامه با شماره پیاپی 0 سال 2015
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Abstract
Interleukin-16 (IL-16) is an immunomodulatory cytokine, which plays an important role in some inflammatory and autoimmune diseases such as hepatitis B, which is a major health concern worldwide. In this study, we aimed to investigate the plausible association between IL-16 polymorphism and chronic HBV susceptibility in an Iranian population. In a case-control study, we analyzed rs1131445 polymorphism in the microRNA binding site of the IL-16 gene in 262 patients with chronic hepatitis B and 269 healthy controls, using the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method and DNA sequencing technology to confirm our results. Altogether, in this investigation, a significant association was observed between the IL-16 TC genotype compared with the TT genotype (OR = 0.696, 95% CI: 0.485 - 0.997, P = 0.048), after adjustments for confounders including age and gender. These findings show that immunogenetic factors, such as single nucleotide polymorphism in IL-16, could be a risk factor for susceptibility to chronic HBV infection. However, further investigations are needed to verify these results
Journal title
Jundishapur Journal of Microbiology (JJM)
Serial Year
2015
Journal title
Jundishapur Journal of Microbiology (JJM)
Record number
2384191
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