Title of article
Development of Membrane Electrode for the Selective determination of Bromazepam in Tablets and Plasma
Author/Authors
Ali، Nesma A نويسنده Department of Chemical Laboratories, Forensic Medicine Authority, Justice Ministry,114 Bairam El Tounsy St., El SayedaZeinab, Cairo, Egypt Ali, Nesma A , Abdelrahman، Maha M نويسنده Pharmaceutical Analytical Chemistry Department, Faculty of Pharmacy, Beni-Suef University, Alshaheed Shehata Ahmad Hegazy St., 62514, Beni-Suef, Egypt Abdelrahman, Maha M , Naguib، Ibrahim A نويسنده Pharmaceutical Analytical Chemistry Department, Faculty of Pharmacy, Beni-Suef University, Alshaheed Shehata Ahmad Hegazy St., 62514, Beni-Suef, Egypt Naguib, Ibrahim A , El Ghobashy، Mohamed R نويسنده Analytical Chemistry Department, Faculty of Pharmacy, Cairo University, Kasr El-Aini St., 11562, Cairo, Egypt El Ghobashy, Mohamed R
Issue Information
دوماهنامه با شماره پیاپی 0 سال 2015
Pages
12
From page
242
To page
253
Abstract
Polyvinyl chloride (PVC) membrane sensor is described and characterized for the determination of a Benzodiazepine drug; bromazepam (BMZ). The sensor based on the use of the ion association complex of BMZ cation with tetraphenyl borate (BMZ-TPB) counter anion as ion exchange sites in the PVC matrix plasticized with dibutylsebathete (DBS) as a solvent mediator. The performance characteristics of thissensor were evaluated according to IUPAC recommendations; achieve a fast, stable and linear response for BMZ over the concentration range 10–6 to 10–2 M with slope of 44.13 mV per concentration decade. The direct potentiometric determination of BMZ using the proposed sensor gave average recovery of 100.05±0.66. The sensor is used for determination of BMZ in pharmaceutical formulations and in plasma. Validation of the method shows suitability of the proposed sensor for use in the quality control assessment of BMZ. The developed method was proved to be simple, accurate and precise when statistically compared with a reference HPLC method
Journal title
Analytical and Bioanalytical Electrochemistry
Serial Year
2015
Journal title
Analytical and Bioanalytical Electrochemistry
Record number
2384765
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