Title of article :
Hepatoprotective activity of Mammea africana ethanol stem bark extract
Author/Authors :
-، - نويسنده Department of Pharmacology and Toxicology Faculty of Pharmacy, University of Uyo, Uyo, Nigeria Okokon, Jude Efiom , -، - نويسنده Department of Pharmacology and Toxicology Faculty of Pharmacy, University of Uyo, Uyo, Nigeria Burata Bawo, Michael , -، - نويسنده Department of Pharmacology and Toxicology Faculty of Pharmacy, University of Uyo, Uyo, Nigeria Orji Mbagwu, Herbert
Issue Information :
دوماهنامه با شماره پیاپی 0 سال 2016
Abstract :
Mammea africana Sabine (Guttiferae) stembark, a common plant, traditionally used to treat various diseases and ailments was evaluated for hepatoprotective potentials against paracetamol- induced liver injury in rats. The hepatoprotective effect of the stembark extract (30-90 mg/kg) was evaluated by the assay of liver function parameters: total and direct bilirubin, serum protein and albumin, total cholesterol, alanine aminotransaminase (ALT), aspartate aminotransaminase (AST), and alkaline phosphatase activities (ALP), antioxidant enzymes: superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), reduced glutathione (GSH) and histopathological study of the liver. The administration of the stembark extract caused significant (p
Journal title :
Avicenna Journal of Phytomedicine AJP)
Journal title :
Avicenna Journal of Phytomedicine AJP)
