Author/Authors :
Bressan، Eriberto نويسنده Department of Neurosciences, University of Padua, Padua, Italy. Bressan, Eriberto , Botticelli، Daniele نويسنده Faculty of Dentistry, University of Medical Science, La Habana, Cuba. , , Sivolella، Stefano نويسنده Department of Neurosciences, University of Padua, Padua, Italy. , , Bengazi، Franco نويسنده Faculty of Dentistry, University of Medical Science, La Habana, Cuba , , Guazzo، Riccardo نويسنده Department of Neurosciences, University of Padua, Padua, Italy , , Sbricoli، Luca نويسنده Department of Neurosciences, University of Padua, Padua, Italy , , Ferroni، Letizia نويسنده Department of Biomedical Sciences, University of Padua, Padua, Italy. Ferroni, Letizia , Gardin، Chiara نويسنده Department of Biomedical Sciences, University of Padua, Padua, Italy. Gardin, Chiara , Urbizo Velez، Joaquin نويسنده Faculty of Dentistry, University of Medical Science, La Habana, Cuba , , Zavan، Barbara نويسنده Department of Biomedical Sciences, University of Padua, Padua, Italy. Zavan, Barbara
Abstract :
The biological interaction between the jaw bones and dental implant is fundamental for the long-term success of
dental implant placement. Nevertheless, the insufficient bone volume remains a major clinical problem,
especially in case of immediate dental implant. Using a canine model, the present study proves the regenerative
potential of adipose- derived stem cells (ADSCs) to repair peri-implant bone defects occurring in immediate
dental implant placement. In six labradors, all mandibular premolars and the first molars were extracted
bilaterally and three months later dental implants were installed with a marginal gap. The marginal defects were
filled with hydroxyapatite (HA)-based scaffolds previously seeded with ADSCs. After one month of healing,
specimens were prepared for histological and histomorphometric evaluations. Histological analyses of ground
sections show that ADSCs significantly increase bone regeneration. Several new vessels, osteoblasts and new
bone matrix were detected. By contrast, no inflammatory cells have been revealed. ADSCs could be used to
accelerate bone healing in peri- implant defects in case of immediate dental implant placement.
