Does Ovulation Induction Increase the Risk of Aneuploid Conception? Comparison of First Trimester Miscarriages after FSH Stimulated Cycles and Naturally Conceived Cycles

Objectives: The aim of this study was to determine the rate of chromosomal abnormalities in the products of first trimester miscarriages in patients who were under FSH ovarian stimulation and to compare the results with the products of miscarriages of naturally conceived pregnancies. Materials and Methods: This retrospective cohort study was conducted over a nine-year period. Included were 909 patients who conceived naturally and 76 infertility patients who were under FSH stimulation with first trimester miscarriages karyotyped. The rate of aneuploidy was compared between the two groups. The main outcome measure was the incidence of aneuploidy. Results: In 76 FSH-induced pregnancies, 12 (15.7%) had an abnormal karyotype. The rate of aneuploidy rate in miscarriages in the natural conception group was 22.3%. There was no statistically significant difference in age (32.7 ± 4.2 vs. 33.5 ± 5.0), cycle day 3 FSH (7.9 ± 2.3 mIU/ml vs. 7.1 ± 2.6 mIU/ml) or exogenous FSH doses (2419.7± 643.7 IU vs. 2616.5 ± 947.5 IU) between the infertile patients with or without abnormal karyotypes. Conclusion: Exposure to exogenous FSH was not associated with increased aneuploidy rates in our infertile population.