Author/Authors :
Hassanzadeh، Sepide نويسنده Biotechnology Research Center, Tehran University of Medical Sciences, Tehran, IR Iran , , Pourmand، Mohammad Reza نويسنده Department of Medical Biotechnology, School of Advanced Technology, Tehran University of Medical sciences, Tehran, IR Iran , , Hadadi، Azar نويسنده Department of Internal Medicine, Research Development Center, Sina Hospital, Tehran University of Medical Sciences, Tehran, IR Iran , , Nourijeylani، Keramat نويسنده Department of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Sciences, Tehran, IR Iran , , Yousefi، Masoud نويسنده , , Mashhadi، Rahil نويسنده Urology Research Center, Tehran University of Medical Sciences, Tehran, Iran , , Askari، Emran نويسنده Mashhad Medical Microbiology Student Research Group, Mashhad University of Medical Sciences, Mashhad, IR Iran AND Student Research Committee, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, IR Iran. Askari, Emran
Abstract :
Background: Methicillin-Resistant Staphylococcus aureus (MRSA) is the one of most commonly isolated organisms from clinical samples which can cause lifethreatening infections. The emergence and spread of antibiotic resistance makes the treatment of these infections more complicated. In this study, we aimed to determine the patterns of antibiotic resistance among MRSA isolates from Tehran, Iran. Methods: From December 2012 to April 2014, 120 clinical samples were collected. MRSA was identified by cefoxitin disc diffusion. Antimicrobial susceptibility testing was performed on MRSA isolates for eight other antibiotics by disc diffusion method according to CLSI (2013) recommendations. Also, the minimum inhibitory concentration (MIC) was determined for vancomycin by MIC test strips. Results: According to disc diffusion, 60 (50%) isolates showed resistance to cefoxitin. Among these isolates, the rate of resistance to nitrofurantoin, vancomycin, teicoplanin, doxycycline, trimethoprim, erythromycin, clindamycin, and ciprofloxacin were 0%, 0%, 0%, 28.3%, 28.3%, 58.3%, 63.3%, and 70%, respectively. All isolates were susceptible to vancomycin according to disc diffusion and MIC. Conclusion: Compared to other reports from Iran, our study indicated a moderate rate for MRSA. However, the rates of resistance to generally prescribed antibiotics in these isolates were high. In this situation, it is recommended to monitor the antibiotic resistance in these hospitals
