Study of Antibacterial Effect of Novel Thiazole, Imidazole and Tetrahydropyridine Derivatives against Escherichia coli

Introduction: Escherichia coli is one of the important pathogens in human with global importance. Because of the necessity for identification and the use of novel antibacterial compounds against E. coli, in this present study we focused on the antibacterial effects of synthesized thiazole, imidazole and tetrahydropyridine derivatives on E. coli. Methods: For evaluation of antibacterial effect, the disk diffusion method was applied to measure the growth inhibition zone diameter and broth micro-dilution was performed to determine the minimum inhibitory concentration (MIC). Results: Assessing the antibacterial effect showed that only 6d derivative of thiazole had inhibitory effect on E. coli and the other thiazole, imidazole and tetrahydropyridine derivatives lacked any inhibitory result on this organism. The inhibitory effect of 6d derivative of thiazole was MIC=125 and growth inhibition zone diameter of 16±0.1. Discussion: The antibacterial effect of thiazole, imidazole and tetrahydropyridine derivatives differs from each other and chemical linkages such as oxygen to thiazole ring in 6d derivative, could have reinforced this effect. The next step is determination of the toxicity and therapeutic effects in the laboratory animals