Author/Authors :
Meighani، Ghasem نويسنده Department of Pediatrics Dentistry, School of Dentistry, Tehran University of Medical Sciences, Tehran, Iran Meighani, Ghasem , Aghamohammadi، Asghar نويسنده , , Javanbakht، Honarmand نويسنده Department of Pediatrics Dentistry, School of Dentistry, Tehran University of Medical Sciences, Tehran, Iran Javanbakht, Honarmand , Abolhassani، Hassan نويسنده , , Nikayin، Sina نويسنده Research Center for Immunodeficiencies, Pediatrics Center of Excellence, Childrens Medical Center, Tehran University of Medical Sciences, Tehran, Iran Nikayin, Sina , Jafari، Seyed Mehryar نويسنده Research Center for Immunodeficiencies, Pediatrics Center of Excellence, Childrens Medical Center, Tehran University of Medical Sciences, Tehran, Iran Jafari, Seyed Mehryar , Ghandehari Motlagh، Mehdi نويسنده School of Dentistry, Pediatric Dentistry , , Shamshiri، Ahmad Reza نويسنده , , Rezaei، Nima نويسنده ,
Abstract :
Primary antibody deficiencies (PAD) are a group of immune system disorders, associated with decreased levels of secretory and protective immunoglobulins. Because of the important role of immunoglobulins in the protection of oral cavity, patients with PADs are more susceptible to dental caries or oral manifestations.
This study was performed to investigate the oral and dental manifestations of PADs patients. In this study, 33 patients with PADs (21 common variable immunodeficiency, 8 X- linked agammaglobulinemia and 4 hyper IgM syndrome) and 66 controls were examined; the number of decayed, missed and filled teeth (DMFT) were investigated.
Aphthous was the most frequent manifestation in PADs patients (38.7%), which wassignificantly16.7% higher than the controls (p=0.03). The patients with PADs showed significantly higher presentation of other oral and dental manifestations, including herpes sores, candidiasis tonsillitis, gingivitis, calculus, enamel hypoplasia and other ulcerations. The mean DMFT scores were 6.15±3.6 and 1.93±0.4 in PADs patients and controls, respectively (p<0.001). Although the patients with common variable immunodeficiency had higher means of DMFT in comparison with other groups of PADs, this difference was not statistically significant.
This study showed significantly higher frequency of oral and dental manifestations in the patients with PADs compared to controls. Therefore, regular examination of oral cavity could be suggested in this group of immunodeficient patients.
