Author/Authors :
Samareh Fekri، Mitra نويسنده Department of Internal Medicine, Afzalipour Hospital, Kerman, Iran. , , Shokoohi، Mostafa نويسنده Physiology Research Center, Regional Knowledge Hub for HIV/AIDS Surveillance, Kerman , , Gozashti، Mohammad Hossein نويسنده Department of Endocrinology, Metabolism and Physiology Research Center, Kerman University of Medical Sciences, Kerman, Iran. , , Esmailian، Saeed نويسنده Research Committee, Kerman University of Medical Sciences, Kerman, Iran Esmailian, Saeed , Jamshidian، Nasrollah نويسنده Research Committee, Kerman University of Medical Sciences, Kerman, Iran Jamshidian, Nasrollah , Shadkam-Farokhi، Malihe نويسنده Physiology Research Center, Kerman University of Medical Sciences, Kerman, Iran Shadkam-Farokhi, Malihe , Lashkarizadeh، Mohammad Reza نويسنده Department of Surgery, Afzalipour Hospital, KERMAN-IRAN. , , Malekpour Afshar، Reza نويسنده Department of Pathology, Kerman University of Medical Sciences, Kerman, Iran. Malekpour Afshar, Reza
Abstract :
About 8% of the general population suffers from autoimmune diseases, from which 78% are women. One of the most important causes of thyroid diseases is autoimmunity in origin, and it seems that people with thyroid diseases present more signs of asthma. This study was therefore designed to investigate the frequency of autoimmune thyroid diseases in women suffering from bronchial asthma.
In a cross-sectional study, 100 women with asthma and 100 women as control group were tested for thyroid function and anti-thyroid peroxidase antibody (anti-TPO Ab) measurements. The asthmatic patients were selected based on having chronic cough, dyspnea, wheezing and clinical examination of the chest. The diagnosis was confirmed by pulmonary function tests. Blood tests were done by electrochemiluminescence immunoassay method.
No hyperthyroid patient was found in either group. Serum TSH and Total T4 levels were not statistically different between the two groups, but serum anti-TPO Ab levels in women with asthma (74±13.6 IU/ml) was significantly higher than control group (45.24±10.56 IU/ml). After adjusting the effect of age and BMI, the relationship between asthma and anti- TPO Ab (>50 IU/ml) was statistically significant (OR=3.3, P<0.01).
Positive anti-TPO Ab in asthmatic patients may show presence of a hidden autoimmune thyroiditis in these patients. We suggested checking asthmatic patients for thyroid diseases.
