Author/Authors :
Honarmand، Marieh نويسنده Department of Oral Disease, Faculty of Dentistry, Zahedan University of Medical Sciences, Zahedan, Iran Honarmand, Marieh , Saravani، Shirin نويسنده Department of Oral & Maxillofacial Pathology, Faculty of Dentistry, Zahedan University of Medical Science, Zahedan, Iran Saravani, Shirin , Kamyab، Nazanin نويسنده Department of Oral Medicine, School of Dentistry,
Rafsanjan University of Medical Sciences, Rafsanjan, IR
Iran , , Jahantigh، Mehdi نويسنده Pathology Department, Faculty of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran , , Torabi Parizi، Molouk نويسنده Department of Oral and Maxillofacial Pathology, School of
Dentistry, Kerman University of Medical Sciences, Kerman, IR
Iran ,
Abstract :
It has been demonstrated that HER3 plays an important role in some human cancers and the HER3 expression is associated with worse survival in solid tumors. This study was conducted to compare HER3 expression in epithelial lining of radicular cysts (RCs), dentigerous cysts (DCs) and odontogenic keratocysts (OKCs). This was a descriptive-analytical study, which assessed all 57 paraffin blocks of RCs, DCs and OKCs (21 RCs, 16 DCs, 20 OKC) from pathological archive of Dentistry College of Zahedan, Iran. The HER3 expression in cytoplasm and membrane was examined by immunohistochemical method. The data collected was analyzed using SPSS16 by ANOVA and Chi-square. P < 0.05 was considered as statistically significant. The HER3 expression had positive results in 52.4% of OKC, 50% of DC and only 20% of RC samples. There was a significant difference between HER3 expression in OKCs and RCs. The HER3 expression in developmental odontogenic cysts was higher than that in inflammatory odontogenic cysts. The higher rate of HER3 expression in OKC may justify inherent growth potential, stimulation-independent proliferation capability, invasive growth and high recurrence rate of the cyst accepted today as a tumor
