Author/Authors :
Mousavi ، Seyed Amir نويسنده Torabinejad Dental Research Center, Department of Endodontics, Dental School, Isfahan University of Medical Sciences, Isfahan, Iran Mousavi , Seyed Amir , Ghoddusi، Jamileh نويسنده Dental Research Center and Department of Endodontics, Dental School, Mashhad University of Medical Sciences, Mashhad, Iran , , Mohtasham، Nooshin نويسنده , , Shahnaseri ، Shirin نويسنده Dental Implant Research Center, Department of Oral and Maxillofacial Surgery, Dental School, Isfahan University of Medical Sciences, Isfahan, Iran Shahnaseri , Shirin , Paymanpour ، Payam نويسنده Department of Endodontics, Dental School, Shahid Beheshti University of Medical Sciences, Tehran, Iran Paymanpour , Payam , Kinoshita ، Jun-Ichiro نويسنده Department of Conservative Dentistry, Showa University Dental Hospital, Tokyo, Japan Kinoshita, Jun-Ichiro
Abstract :
ABSTRACT
Introduction: The aim of this randomized clinical trial was to compare the histologic pulp tissue response to one-step direct pulp capping (DPC) and miniature pulpotomy (MP) with mineral trioxide aggregate (MTA) after application of dexamethasone in healthy human premolars. Methods and Materials: Forty intact premolars from 10 orthodontic patients, were randomly chosen for DPC (n=20) or MP (n=20). In 10 teeth from each group, after exposure of the buccal pulp horn, topical dexamethasone was applied over the pulp. In all teeth the exposed/miniaturely resected pulp tissue was covered with MTA and cavities were restored with glass ionomer. Teeth vitality was evaluated during the next 7, 21, 42, and 60 days. Signs and/or symptoms of irreversible pulpitis or pulp necrosis were considered as failure. According to the orthodontic schedule, after 60 days the teeth were extracted and submitted for histological examination. The Kruskal-Wallis and Fisher’s exact tests were used for statistical analysis of the data (P=0.05). Results: Although dexamethasone specimens showed less inflammation, calcified bridge, pulpal blood vasculature, collagen fibers and granulation tissue formation were not significantly different between the groups (P > 0.05). Conclusion: Topical dexamethasone did not hindered pulp healing but reduced the amount of underlying pulpal tissue inflammation after DPC and MP in healthy human premolars.
Keywords: Dexamethasone; Direct Pulp Capping; Mineral Trioxide Aggregate; Miniature Pulpotomy; Vital Pulp Therapy
