Author/Authors :
Zarrabian ، Shahram نويسنده Institute for Cognitive Science Studies (ICSS), Tehran, Iran , , Nasehi ، Mohammad نويسنده Cognitive and Neuroscience Research Center (CNRC), Tehran Medical Sciences Branch, Islamic Azad University, Tehran, Iran , , Zarrindast، Mohammad Reza نويسنده ,
Abstract :
In the current study, we assessed the role of transient receptor potential (TRP) channels on avoidance memory and anxiety states in CA3 area of the hippocampus. We explored the anxiety and avoidance memory states using test-retest protocol in the elevated plus maze to understand whether TRP channels can affect the above mentioned states in CA3 area. To investigate the consolidation phase of memory, the drugs were injected into the CA3 region before the test. Our data showed that the application of SKF-96365 did not alter anxiety-like behaviors but induced avoidance memory impairment. It was revealed that CA3 TRP channels
