Title of article
Difference in transient ischemia-induced neuronal damage and glucose transporter-1 immunoreactivity in the hippocampus between adult and young gerbils
Author/Authors
-، - نويسنده Department of Emergency Medicine, School of Medicine, Kangwon National University, Chuncheon 200-701, South Korea|Department of Emergency Medicine, Sacred Heart Hospital, College of Medicine, Hallym University, Anyang431-796, South Korea Min Park, Seung , -، - نويسنده Department of Neurobiology, School of Medicine, Kangwon National University, Chuncheon 200-701, South Korea Lee, Jae-Chul , -، - نويسنده Department of Physiology, College of Medicine, Hallym University, Chuncheon 200-702, South Korea Hui Chen, Bai , -، - نويسنده Department of Physiology, College of Medicine, Hallym University, Chuncheon 200-702, South Korea Shin, Bich-Na , -، - نويسنده Department of Neurobiology, School of Medicine, Kangwon National University, Chuncheon 200-701, South Korea Hwi Cho, Jeong , -، - نويسنده Department of Neurobiology, School of Medicine, Kangwon National University, Chuncheon 200-701, South Korea Hye Kim, In , -، - نويسنده Department of Neurobiology, School of Medicine, Kangwon National University, Chuncheon 200-701, South Korea Ha Park, Joon , -، - نويسنده Department of Neurobiology, School of Medicine, Kangwon National University, Chuncheon 200-701, South Korea Won, Moo-Ho , -، - نويسنده Department of Biomedical Science, Research Institute of Bioscience and Biotechnology, Hallym University, Chuncheon 200-702, South Korea Hyeon Ahn, Ji , -، - نويسنده Department of Biomedical Science, Research Institute of Bioscience and Biotechnology, Hallym University, Chuncheon 200-702, South Korea Tae, Hyun-Jin , -، - نويسنده Department of Emergency Medicine, School of Medicine, Kangwon National University, Chuncheon 200-701, South Korea Cheol Shin, Myoung , -، - نويسنده Department of Emergency Medicine, School of Medicine, Kangwon National University, Chuncheon 200-701, South Korea Woo Park, Chan , -، - نويسنده Department of Emergency Medicine, School of Medicine, Kangwon National University, Chuncheon 200-701, South Korea Hwi Cho, Jun , -، - نويسنده Department of Internal Medicine, School of Medicine, Kangwon National University, Chuncheon 200-701, South Korea Young Lee, Hui
Issue Information
ماهنامه با شماره پیاپی 0 سال 2016
Pages
8
From page
521
To page
528
Abstract
-
Abstract
Objective(s): The alteration of glucose transporters is closely related with the pathogenesis of brain edema. We compared neuronal damage/death in the hippocampus between adult and young gerbils following transient cerebral ischemia/reperfusion and changes of glucose transporter-1(GLUT-1)-immunoreactive microvessels in their ischemic hippocampal CA1 region. Materials and Methods: Transient cerebral ischemia was developed by 5-min occlusion of both common carotid arteries. Neuronal damage was examined by cresyl violet staining, NeuN immunohistochemistry and Fluoro-Jade B histofluorescence staining and changes in GLUT-1 expression was carried out by immunohistochemistry. Results: About 90% of pyramidal neurons only in the adult CA1 region were damaged after ischemia/reperfusion; in the young, about 53 % of pyramidal neurons were damaged from 7 days after ischemia/reperfusion. The density of GLUT-1-immunoreactive microvessels was significantly higher in the young sham-group than that in the adult sham-group. In the ischemia-operated-groups, the density of GLUT-1-immunoreactive microvessels was significantly decreased in the adult and young at 1 and 4 days post-ischemia, respectively, thereafter, the density of GLUT-1-immunoreactive microvessels was gradually increased in both groups after ischemia/reperfusion. Conclusion: CA1 pyramidal neurons of the young gerbil were damaged much later than that in the adult and that GLUT-1-immunoreactive microvessels were significantly decreased later in the young. These data indicate that GLUT-1 might differently contribute to neuronal damage according to age after ischemic insults.
Journal title
Iranian Journal of Basic Medical Sciences
Serial Year
2016
Journal title
Iranian Journal of Basic Medical Sciences
Record number
2389864
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