Author/Authors :
Mazdeh، Mehrdokht نويسنده Department of Neurology, Hamadan University of Medical Sciences, Hamadan, IR Iran , , Seifirad، Soroush نويسنده Research Fellow, Department of Cardiology, Children Medical Center, Tehran University of Medical Sciences, Tehran, Iran , , Kazemi، Niloofar نويسنده Medical Student, Hamadan University of Medical Sciences, Hamadan, Iran. Kazemi, Niloofar , Seifrabie، Mohammad Ali نويسنده Department of Social Medicine, Hamadan University of Medical Sciences, Hamadan, Iran. Seifrabie, Mohammad Ali , Dehghan، Arash نويسنده Department of Pathology, School of Medicine, Hamedan University of Medical Sciences, Hamedan, Iran , , Abbasi، Hamidreza نويسنده Trauma Research Center, Shahid Rajaee (Emtiaz) Trauma Hospital, Shiraz University of Medical Sciences, Shiraz, Iran ,
Abstract :
Multiple risk factors are introduced for Multiple Sclerosis (MS). Recent studies have suggested a possible correlation between vitamin D deficiency and an increase risk of MS. This study was therefore undertaken to compare vitamin D levels in new cases of MS and their relatives as healthy controls. Seventy five new diagnosed MS patients and 100 matched healthy controls among their relatives were enrolled in this study. Two groups were matched for gender, age, season in which serum level of vitamin D was checked and region and diet. Serum levels of 25-hydroxy vitamin D was measured, recorded and analyzed. Seventy five patients (57 female and 18 male) and 100 healthy subjects (75 female and 25 male) were enrolled in this study. The mean serum levels of 25-hydroxy vitamin D in case and control groups were 11.31 and 17.9 ng/ml, respectively (P=0.003). Compared to the healthy subject, serum levels of vitamin D were significantly lower in patients with MS. This difference was only significant in women. Observed difference of vitamin D levels of both groups were significant in summer. This study continues to support the role of vitamin D deficiency in MS.
