Author/Authors :
Mehdikhani-Nahrkhalaji، Mehdi نويسنده Department of Biomedical Engineering, Faculty of Engineering, University of Isfahan , , Fathi، Mohammad Hossein نويسنده , , Mortazavi، Vajihesadat نويسنده , , Mousavi، Sayed Behrouz نويسنده Torabinejad Dental Research Center, Department of Endodontics , , Akhavan، Ali نويسنده Dental Materials Research Center, Department of Endodontics , , ESLAMI HAGHIGHAT، Abbas نويسنده , , Hashemi-Beni، Batool نويسنده 7Dental Materials Research Center, Department of Anatomical Sciences, School of Medicine, Isfahan University of Medical Sciences , , Razavi، Sayed Mohammad نويسنده Department of Oral and Maxillofacial Pathology, Isfahan University of Medical Sciences, Isfahan, Iran , , Mashhadiabbas، Fatemeh نويسنده Department of Pathology, Dental Research Center of Shahid Beheshti University of Medical Science, Tehran, Iran ,
Abstract :
Background: The aim of this study was to evaluate the interaction of bioactive and biodegradable
poly (lactide-co-glycolide)/bioactive glass/hydroxyapatite (PBGHA) and poly (lactide-co-glycolide)/
bioactive glass (PBG) nanocomposite coatings with bone.
Materials and Methods: Sol-gel derived 58S bioactive glass nanoparticles, 50/50 wt% poly (lactic
acid)/poly (glycolic acid) and hydroxyapatite nanoparticles were used to prepare the coatings. The
nanocomposite coatings were characterized by scanning electron microscopy, X-ray diffraction and
atomic force microscopy. Mechanical stability of the prepared nanocomposite coatings was studied
during intramedullary implantation of coated Kirschner wires (K-wires) into rabbit tibia. Titanium
mini-screws coated with nanocomposite coatings and without coating were implanted intramedullary
in rabbit tibia. Bone tissue interaction with the prepared nanocomposite coatings was evaluated
30 and 60 days after surgery. The non-parametric paired Friedman and Kruskal-Wallis tests were
used to compare the samples. For all tests, the level of signifi cance was P < 0.05.
Results: The results showed that nanocomposite coatings remained stable on the K-wires with a
minimum of 96% of the original coating mass. Tissue around the coated implants showed no adverse
reactions to the coatings. Woven and trabecular bone formation were observed around the coated
samples with a minimum infl ammatory reaction. PBG nanocomposite coating induced more rapid
bone healing than PBGHA nanocomposite coating and titanium without coating (P < 0.05).
Conclusion: It was concluded that PBG nanocomposite coating provides an ideal surface for
bone formation and it could be used as a candidate for coating dental and orthopedic implants.
