Author/Authors :
Zare، Sona نويسنده Skin and Stem Cell Research Center, Tehran University of Medical Sciences, Tehran, Iran , , Ahmadi، Reza نويسنده Specialist in infection diseases, 22-Bahman Hospi-tal , , Rostamzadeh، Ayoob نويسنده Department of Anatomical Sciences, Kurdistan University of Medical Sciences, Sanandaj, Iran Rostamzadeh, Ayoob , Kurd، Soleiman نويسنده Department of Biological Sciences and Biotechnology, School of Science, University of Kurdistan , , Hejazi، Somayeh نويسنده Department of Dermatology, Skin Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran. , , Fard، Maryam نويسنده Department of Anatomical Science, Faculty of Medicine, Qazvin University of Medical Sciences, Qazvin, IR Iran , , AnjomShoa ، Maryam نويسنده Dept. of Anatomical Science, School of Dentistry, Isfahan (Khorasgan) Branch, Islamic Azad University, Isfahan, Iran. , , Nilforoushzadeh، Mohammad Ali نويسنده ,
Abstract :
Connective tissue cells include fibroblasts, chondrocytes, adipocyte, and osteocytes. These cells are specialized for the secretion of collagenous extracellular matrix and are responsible for the architectural framework of the human body. Connective tissue cells play a central role in supporting as well as repairing tissues and organs. Fibroblast cell therapy could be used for the treatment of burn wounds, scars, diabetic foot ulcers, acne scars and skin aging. This review focused on biology of fibroblasts and their role in cell therapy of recessive dystrophic epidermolysis bullosa (RDEB). Fibroblasts are known to play a pivotal role in skin structure and integrity, and dermal fibroblasts are believed to promote skin regeneration and rejuvenation via collagen production. Fibroblasts can be used in transplantations to ameliorate an immune system response, in order to reduce antigen production. Human fibroblasts suppress ongoing mixed lymphocyte reactions (MLRs) between lymphocyte cells from two individuals, and supernatant materials from fibroblast cultures suppress MLRs.
