Seroprevalence of Toxoplasmosis in HIV+/AIDS Patients in Iran
Mohraz، Minoo نويسنده , , Mehrkhani، Farhad نويسنده , , Jam، Sara نويسنده , , SeyedAlinaghi، Seyed Ahmad نويسنده Iranian Research Center for HIV/AIDS, Tehran University of Medical Sciences, Tehran, Iran. SeyedAlinaghi, Seyed Ahmad , Sabzvari، Duman نويسنده , , Fattahi، Fatemeh نويسنده , , Jabbari، Hossain نويسنده , , Hajiabdolbaghi، Mahboubeh نويسنده Department of Infectious Diseases, Iranian Research Center for HIV and AIDS, Emam Khomeini Hospital, Tehran University of Medical Sciences, Tehran, IR Iran ,
Toxoplasma gondii has arisen as an important opportunistic agent especially in the central nervous system and in advanced HIV disease can cause significant morbidity and mortality. This study was carried out to determine the seroprevalence of toxoplasmosis among HIV-positive patients in Iran. Blood samples were collected from 201 HIV-positive patients and anti-toxoplasma antibodies were detected by using conventional ELISA. An antibody titer of >3 IU/ml was considered positive. The majority of studied patients were male (male to female ratio: 5 to 1) with the mean age of 36 ± 1 yrs. The seroprevalence of toxoplasmosis in HIV-positive patients was 49.75%. The mean CD4 count in HIV patients with positive toxoplasma serology was 332.5 ± 22.4 cells/µl. Only 1% of the patients had IgM anti-toxoplasma antibodies and 10% of the patients had clinical toxoplasma encephalitis. The mean CD4 count in this group was 66.4 ± 15.5 cells/µl and there was a significant association between CD4 count and rate of toxoplasma encephalitis (P