Author/Authors :
Youssry، Mohamed نويسنده , , Ozmen، Batuhan نويسنده , , Orief، Yasser نويسنده Department of Obstetrics and Gynecology, University of Alexandria, Alexandria, Egypt. , , Zohni، Khaled نويسنده Medical Sciences Division, Reproduction Unit, National Research Center, Egypt. , , Al-Hasani، Safaa نويسنده Department of Obstetrics and Gynecology, University of Schleswig – Holstein, Luebeck, Germany ,
Abstract :
Fertilization involves direct interaction of the sperm and oocyte, fusion of the cell
membranes and union of male and female gamete genomes. The completion of this
process and subsequent embryo development depend in part on the inherent integrity of
the sperm DNA. Sperm genome quality has been emphasized for several years as
playing a major role in early embryogenesis. There is clinical evidence showing that
human sperm DNA damage may adversely affect reproductive outcomes and that
spermatozoa of infertile men possess substantially more DNA damage than do
spermatozoa of fertile men. Testing DNA integrity may help selecting spermatozoa with
intact DNA or with the least amount of DNA damage for use in assisted reproductive
techniques (ARTs). This review will focus on how sperm DNA is organized, what
causes sperm DNA damage and what impact this damage may have on reproductive
outcome.
