Kinesin-1 Traffic Control in Neuronal Highway

The current study aimed to review research articles concerning kinesin-1 traffic control in the neuronal highways This review article compromised previous studies published since 1980 using PubMed, Google scholar, Embase, Medline, science direct and SID databases according to the keywords. Kinesin-1 often recognizes scaffold proteins or adaptor proteins and binds to cargo membrane proteins directly as part of a protein complex. Several kinases and microtubule associated proteins are identified in the regulation of motor-cargo unloading. The mechanisms by which kinesin-1 recognizes and binds to specific cargos, and how to unload cargo and determine the direction of transport, are now identified. In summary, the current review article demonstrated that some proteins such as adaptors, Scaffolds, chaperons and microtubule associated proteins and some metabolites, hormones, protein kinases and exercise training can regulate kinesin-1 traffic control in neuronal highway. These findings open exciting new areas of kinesin-1 research.