Author/Authors :
Salehi، Maryam نويسنده Neuroscience Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran. Salehi, Maryam , Jafari، Mahvash نويسنده , , Asgari، Alireza نويسنده Exercise Physiology Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran , , Salimian، Mohammad نويسنده Department of Biochemistry, Baqiyatallah University of Medical Sciences, Tehran, IR Iran , , Abbasnezhad، Maryam نويسنده Department of Biology, Faculty of Sciences, Payame Noor University, Tehran, IR Iran , , Haji-Hosseini ، Reza نويسنده Haji-Hosseini , Reza , Hajigholamali، Mansoureh نويسنده Department of Biology, Faculty of Sciences, Payame Noor University, Tehran, IR Iran ,
Abstract :
Background
Diazinon (DZN) is one of the most organophosphates that widely used in agriculture and ectoparasiticide formulations. Its extensive use as an effective pesticide was associated with the environmental deleterious effects on biological systems.
Objectives
The aim of this study was to investigate the potency of DZN to affect serum biochemical parameters and the antioxidant defense system in the liver and kidney of two rat strains.
Materials and Methods
In this experimental study, 30 female Wistar and 30 female Norway rats were randomly divided into control and DZN groups. DZN group was divided into four subgroups: 25, 50, 100 and 200 mg/kg of DZN administered groups by i.p. injection. The parameters were evaluated after 24 hours.
Results
At higher doses of DZN, superoxide dismutase, catalase, glutathione S-transferase and lactate dehydrogenase activities and glutathione (GSH) and malondialdehyde levels in liver and kidney of Wistar rats were higher than Norway rats. At these concentrations, DZN increased some serum biochemical indices such as liver enzymes activities and levels of urea, uric acid and creatinine in Wistar rat.
Conclusions
DZN at higher doses alters the oxidant-antioxidant balance in liver and kidney of both rat strains and induces oxidative stress, which is associated with a depletion of GSH and increased lipid peroxidation. However, Wistar rats are found to be more sensitive to the toxicity of DZN compared to Norway rats. In addition, the effect of DZN on liver antioxidant system was more than kidney.
