Effects of Aqueous Extract of Purslane (Portulaca oleracea) on Hepatic Enzymes in Two Models of Renal Ischemia-Reperfusion Injury in Rats

Objectives This study investigated the effect of purslane on hepatic enzymes following renal ischemia-reperfusion (IR) injury in rats by two methods. Materials and Methods In this experimental study, 36 male Wistar rats randomly divided into 6 groups (n = 6): I) previously nephrectomized control, II) simultaneously nephrectomized control, III) previously nephrectomized + IR, IV) simultaneously nephrectomized + IR, V) previously nephrectomized treated by aqueous extract of P. oleracea L. + IR, VI) simultaneously nephrectomized treated by aqueous extract of P. oleracea L. + IR control and ischemia-reperfusion groups received vehicle and treatment groups received aqueous extract of purslane (300 mg/kg). In model 1, the right kidney was nephrectomized, 20 days prior to experiment, in model 2; nephrectomy was done just before induction of 45 minutes ischemia and 24 hours reperfusion to the left kidney. Results Hepatic enzymes were elevated after induction of ischemia reperfusion. Administration of purslane decreased hepatic enzymes. Conclusions Purslane prevented liver damage more effectively in simultaneously nephrectomized model.