Author/Authors :
Norouzpour، A نويسنده MD, Eye Research Center, Khatam-Al-Anbia Eye Hospital, Mashhad University of Medical Sciences (MUMS), Mashhad, Iran , , Hooshyar، Z نويسنده MSc, Department of Mechanical Engineering, Mechanical Engineering College, Shiraz University, Shiraz, Iran , , Mehdizadeh، A نويسنده MD-PhD, Department of Medical Physics, School of Medicine, Shiraz University of Medical Sciences (SUMS), Shiraz, Iran University of Mashhad, Mashhad, Iran ,
Abstract :
Background: Autoregulation of blood flow is a marvelous phenomenon balancing
blood supply and tissue demand. Although many chemically-based explanations
for this phenomenon have been proposed and some of them are commonly used
today, biomechanical aspects of this phenomenon was neglected. The biomechanical
aspect provides insights to us to model vessel diameter changes more precisely and
comprehensively. One important aspect of autoregulation phenomenon is temperature
changes of the tissue resulted from tissue metabolism. We hypothesize that temperature
changes can affect the mechanical properties of the vessel wall leading to vessel
diameter changes during autoregulation. Mechanical modeling of vessel diameter
changes can also be useful to explain other phenomena in which the vessel diameter
changes in response to temperature alterations. Through the mechanical modeling of
any vessel, the analysis of temperature-induced changes in vessel diameter can be
done more precisely.
