Author/Authors :
Soleimanpour، Maryam نويسنده Road Traffic Injury Research Center, Tabriz University of Medical Sciences, Tabriz, Iran , , Imani، Farnad نويسنده Department of Anesthesiology and Pain Medicine, Rasoul-Akram Medical Center, Iran University of Medical Sciences (IUMS), Tehran, Iran , , Safari، Saeid نويسنده Department of Anesthesiology and Critical Care, Iran University of Medical Sciences, Tehran, IR Iran , , Sanaie، Sarvin نويسنده Tuberculosis & Lung Research Center, Tabriz University of Medical Sciences, Tabriz, Iran. , , Soleimanpour، Hassan نويسنده Cardiovascular Research Center, Tabriz University of Medical Sciences, Tabriz, IR Iran , , Ameli، Hoorolnesa نويسنده Students’ Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran , , Alavian، Seyed-Moayed نويسنده ,
Abstract :
Patients with hepatic dysfunction suffer from many problems and associated complications in organs other than the liver. Therefore, it is very important to investigate the effects of different drugs in the treatment of these patients. Due to the high consumption of non-steroidal anti-inflammatory drugs (NSAIDs), studying the effects of these drugs in patients with hepatic dysfunction is particularly important. Research studies published from 1958 to 2014 were investigated in the present study. The literature search was conducted based on the following keywords: non-steroidal anti-inflammatory drugs (NSAIDs), liver dysfunction, cirrhosis, pharmaceutical complications, drug-induced liver injury (DILI), and similar words from reliable resources. In total, 63 articles and two books (out of 179 initially identified resources) were included in the study. In addition to significant hemostatic disorders and cardiovascular disorders, disorders of the renal, respiratory, and gastrointestinal systems, as well as disorders of the central nervous system, occur in patients with hepatic dysfunction. The various NSAIDs have different effects on different bodily systems. Therefore, the appropriate drug should be chosen based on both the condition of the disease and the severity of the dysfunction. Due to the potential adverse effects of NSAIDs in patients with hepatic disease, their impact on all bodily systems should be emphasized when determining whether their use is necessary. Further, the appropriate medication should be selected after a careful assessment of the severity of the disease and any associated complications. It is logical that medicines should only be prescribed by a qualified physician.
