Wound Healing Effect of Satureja Khuzistanica and Satureja Rechingeri Ethanolic Extracts in NMRI Adult Mice

Background Scientists are trying to find ways for skin wound healing. The potential role of plants on wound healing is of interest and controversial. Objectives In this study, the effects of topical application of Satureja Khuzestanica and Satureja Rechingeri methanolic extract on skin wound healing in mice has been evaluated. Satureja Khuzestanica and satureja Rechingeri has anti-oxidant and anti-inflammatory properties and may enhance wound healing process. Materials and Methods For this experimental study, 48 healthy male mice were randomly designated to four groups of A, B, C and D which, respectively treated with, Satureja Khuzestanica extract, and satureja Rechingeri extract, methanol 98% for 22 days. Circular wounds were made in three layers of skin with 10mm diameter in all three layers (dermis, epidermis, and hypodermis). Specimens were taken at 3rd day, 7^th day, 14^st day and 22^th day for microscopic examinations. Results Compare H and E staining sections in the study groups showed that Satureja Rechingeri treated group has best effect on the wound healing in the comparison with placebo at 7^th day, 14^st day and don’t ameliorate wound at 22^th day of treatment. Conclusions The results showed that Satureja Khuzestanica extract not suitable for wound healing. Satureja Rechingeri extract the fourteenth day is appropriate for healing and this plant has been limited period.