Author/Authors :
Zahed Pasha، Yadollah نويسنده Babol University of Medical Sciences, Babol, IR
Iran , , Akbarianrad، Zahra نويسنده Non-Communicable Pediatric Diseases Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, IR Iran. Akbarianrad, Zahra , Yahyaee Shahandashti، Alireza نويسنده Non-Communicable Pediatric Diseases Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, IR Iran. Yahyaee Shahandashti, Alireza , Ahmadpour-Kacho، Mousa نويسنده , , Haghshenas Mojaveri، Mohsen نويسنده Non-Communicable Pediatric Diseases Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, IR Iran. Haghshenas Mojaveri, Mohsen
Abstract :
Background: Feeding intolerance is prevalent in very low birth weight (VLBW) neonates and is obstacle for better and faster growth in this group of infants. Some studies have supported the administration of oral probiotic in decrease of feeding intolerance. The aim of this study was to evaluate the effect of oral probiotic on feeding intolerance in VLBW neonates.
Methods: This randomized clinical trial study was conducted on 60 VLBW neonates who were randomly divided into two equal groups of control and drug (oral probiotic of Pedilact drop). In case group, the infants received oral probiotic in addition to routine therapy. Duration of hospitalization, time to reach to full enteral feeding and birth weight, the numbers of vomiting, mortality, c-reactive protein (CRP) rising, daily weight gain and the numbers of defecation were compared between two groups. P-value <0.05 was considered significant.
Results: No significant differences were observed between two groups in regard with gender, birth weight, method of delivery and gestational age. Mean of duration of hospitalization was 42.27 and 31.6 days in control and drug groups, respectively and there was significant difference between two groups (P-value=0.005). There was no significant difference between two groups in terms of reaching full enteral feeding, the numbers of vomiting, time to reach to birth weight, CRP rising, daily weight gain and the numbers of defecation but these results were better in probiotic than control group .
Conclusions: This study showed that prophylactic administration of probiotic was significant in reducing the duration of hospitalization of VLBW neonates and was effective in time to full enteral feeding. It is suggested that the administration of probiotic can be helpful for feeding tolerance in VLBW neonates.
