Author/Authors :
Payandeh، Mehrdad نويسنده Dept. of Hematology and Medical Oncology, Kermanshah University of Medical Sciences, Kermanshah, Iran , , Raeisi، Dariyush نويسنده Faculty of Medicine , , Sohrabi، Nasrollah نويسنده Department of Medical Laboratory Sciences, Para medicine Faculty, Kermanshah University of Medical Sciences, Kermanshah, Iran. Sohrabi, Nasrollah , Zare، Mohammad Erfan نويسنده , , Kansestani، Atefeh Nasir نويسنده Medical Biology Research Center, Kermanshah University of Medical Science, Kermanshah, Iran ; Student Research Committee, Kermanshah University of Medical Science, Kermanshah, Iran. Kansestani, Atefeh Nasir , Keshavarz، Nazanin نويسنده Student research committee, , , Gholami، Samira نويسنده Student Research Committee, Kermanshah University of Medical Sciences, Kermanshah, Iran. Gholami, Samira , Hashemian، Amir Hossein نويسنده ,
Abstract :
ITP is an autoimmune blood disorder in which platelet destruction is mediated by anti-platelet antibodies. The mechanisms of anti-platelet antibodies development are still a little known. The rate of some bacterial or viral agents in cause of ITP is well known. Recently, some study proposed that H pylori infection may be associated with ITP and H pylori eradication can improves platelet counts in infected ITP patients.A baseline platelet count <50×10(3) µL for 4 weeks prior to study entry were required. These patients were tested for H. pylori infection by urea breath. All positive H pylori patients received triple therapy for 7 or 14 days to eradicate H pylori infection. These patients followed for six months.Of 92 patients with ITP, H pylori infection was found in 59.7% (55/92). After excluding patients with confounding factors, 41 patients were remained. After H pylori eradication, CR wasnʹt obtained in any patients. Partial response were obtained only in 3 (7.3%) of the 41 patients and no response in 38 (92.6%) patients. There is a significant difference between the platelet counts of PR and NR groups (P < 0.001).The results of this study and our previously study showed H pylori eradication therapy has beneficial effect for patients with mild thrombocytopenia but the chance of obtaining a response by H pylori treatment is lower in patients with severe thrombocytopenia.
