Author/Authors :
Mojarrab، M. نويسنده Department of Pharmacognosy and Biotechnology, School of Pharmacy, Kermanshah University of Medical Sciences, Kermanshah, I.R. Iran. , , Emami، S.A. نويسنده Department of Pharmacognosy, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, I.R.Iran. , , Gheibi ، Sh نويسنده Associate Professor of Pediatric Gastroenterology, Maternal and Childhood Obesity research Center, Urmia University of Medical Sciences, Shahid Motahari Hospital, Urmia, Iran. drgheibi@umsu.ac.ir , , Taleb، A.M. نويسنده Department of Pharmacogenesis, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran , , Heshmati Afshar، F. نويسنده Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, I.R. Iran. ,
Abstract :
Background and objectives: The plants of genus Artemisia (Asteraceae) have been conventionally used for prevention and medication of a number of ailments. In the present research, ten extracts with different polarities from aerial parts of two Artemisia species, A. kopetdaghensis and A. turcomanica were evaluated for their potential anti-malarial properties. Methods: The plant materials were extracted successively with petroleum ether (PE), dichloromethane (DCM), ethyl acetate (EtOAC), ethanol, and ethanol-water (1:1 v/v) by cold maceration method. Cell free B-hematin formation assay were used for assessing anti-malarial activity of obtained extracts. Results: DCM extract of A. kopetdaghensis and PE extract of A. turcomanica showed remarkable anti-malarial activity with IC50 values of 1.04±0.02 mg/mL and 0.90±0.27 mg/mL, respectively, compared to positive control (chloroquine, IC50 0.04±0.01 mg/mL). Conclusion: It seems that the anti-malarial activity of these extracts might be bound up with the presence of compounds with low or medium polarity; hence, this preliminary test indicated that these potent extracts could be considered for further investigations to find new sources of anti-malarial phytochemicals.
