Study of D/G Hemoglobin incidence in a sample population (single institution)
Arjmandi، Kh نويسنده Assistant professor of pediatric hematology and oncology, Iran University of Medical Sciences, Ali Asghar children’s Hospital Arjmandi, Kh , Faranoush، M نويسنده Assistant professor of hematology and oncology, Semnan University of Medical Sciences, Amir al Momenin Hospital Faranoush, M , Bahoush، Gh نويسنده Assistant professor of pediatric hematology and oncology, Iran University of Medical Sciences, Ali Asghar children’s Hospital Bahoush, Gh , Vossough، P نويسنده Professor of pediatric hematology and oncology, Iran University of Medical Sciences, Ali Asghar children’s Hospital Vossough, P , Hedayatiasl، AA نويسنده Fellowship of pediatric hematology and oncology, Iran University of Medical Sciences, Ali Asghar children’s Hospital Hedayatiasl, AA , Ansari، Sh نويسنده Assistant professor of Pediatrician, Oncologist, Ali-Asghar Children Hospital, Iran University of Medical Sciences, Tehran, Iran , , Shahgholi، E نويسنده Assistant professor of pediatric hematology and oncology, Tehran University of Medical Sciences, Bahrami children’s Hospital Shahgholi, E
Background: The hemoglobin disorders constitute the most prevalent group of monogenic disease A findings consis¬tent with this is a hemoglobin/G variant indicating that the patient has HbD/G trait. Hb D/G traits are clinically benign. In this study, the epidemiology of HbD/G was reviewed in a single institution in Iran.
Methods and Materials: We conducted the epidemiological study at Aliasghar childrenʹs hospital and all patients with HbD/G were entered to this study. The hematological values, hemoglobin electrophoresis, peripheral blood smear and clinical findings were collected in the data special form.
Results: Among 11825 hemoglobin analysis performed, we detected 101 cases of hemoglobin D/G. There were 55.4% male and 44.6% female, median age 9±13.36 yrs. Homozygous of D/G was found in seven pa¬tients with splenomegaly, jaundice, mild anemia and Reticulocytosis. Heterozygote patients were as¬ymptomatic. There wasnʹt any correlation between HbD/G with serum ferritin, MCV, Hb and sex.
Conclusion: In Iran HbD/G is relatively benign condition with mild anemia, Poikylocytosis and minimal hemolysis.