Author/Authors :
Arslan، Fatma Demet نويسنده Department of Medical Biochemistry, Tepecik Training and Research Hospital, Izmir, Turkey , , Serdar، Muhittin نويسنده Department of Medical Biochemistry, Acibadem University School of Medicine, Istanbul, Turkey , , Merve Ari، Elif نويسنده Department of Medical Biochemistry, Tepecik Training and Research Hospital, Izmir, Turkey , , Onur Oztan، Mustafa نويسنده Department of Medical Biochemistry, Tepecik Training and Research Hospital, Izmir, Turkey , , Hikmet Kozcu، Sureyya نويسنده Department of Otolaryngology Head and Neck Surgery, Tepecik Training and Research Hospital, Izmir, Turkey , , Tarhan، Huseyin نويسنده Department of Urology, Tepecik Education and Research Hospital, ?zmir, Turkey , , Cakmak، Ozgur نويسنده Department of Urology, Tepecik Education and Research Hospital, izmir, Turkey , , Zeytinli، Merve نويسنده Department of Medical Biochemistry, Tepecik Training and Research Hospital, Izmir, Turkey , , Yasar Ellidag، Hamit نويسنده Department of Medical Biochemistry, Antalya Training and Research Hospital, Antalya, Turkey ,
Abstract :
Background
In order to apply the right treatment for hemostatic disorders in pediatric patients, laboratory data should be interpreted with age-appropriate reference ranges.
Objectives
The purpose of this study was to determining age-dependent reference range values for prothrombin time (PT), activated partial thromboplastin time (aPTT), fibrinogen tests, and D-dimer tests.
Materials and Methods
A total of 320 volunteers were included in the study with the following ages: 1 month - 1 year (n = 52), 2 - 5 years (n = 50), 6 - 10 years (n = 48), 11 - 17 years (n = 38), and 18 - 65 years (n = 132). Each volunteer completed a survey to exclude hemostatic system disorder. Using a nonparametric method, the lower and upper limits, including 95% distribution and 90% confidence intervals, were calculated.
Results
No statistically significant differences were found between PT and aPTT values in the groups consisting of children. Thus, the reference ranges were separated into child and adult age groups. PT and aPTT values were significantly higher in the children than in the adults. Fibrinogen values in the 6 - 10 age group and the adult age group were significantly higher than in the other groups. D-dimer levels were significantly lower in those aged 2 - 17; thus, a separate reference range was established.
Conclusions
These results support other findings related to developmental hemostasis, confirming that adult and pediatric age groups should be evaluated using different reference ranges.
