Title of article :
Locally Estimated Hemodynamic Response Function and Activation Detection Sensitivity in Heroin-Cue Reactivity Study
Author/Authors :
Maleki-Balajoo، Somayeh نويسنده Department of Biomedical Engineering, Faculty of Electrical Engineering, Khaje Nasir Toosi University of Technology, Tehran, Iran. Maleki-Balajoo, Somayeh , Hossein-Zadeh، Gholam-Ali نويسنده Control and Intelligent Processing Center of Excellence, School of Electrical and Computer Engineering, University of Tehran, Tehran, Iran. Hossein-Zadeh, Gholam-Ali , Soltanian-Zadeh، Hamid نويسنده , , Ekhtiari، Hamed نويسنده Iranian National Center for Addiction Studies (INCAS), Tehran University of Medical Sciences, Tehran, Iran Ekhtiari, Hamed
Issue Information :
فصلنامه با شماره پیاپی 29 سال 2016
Abstract :
Introduction: A fixed hemodynamic response function (HRF) is commonly used for functional magnetic resonance imaging (fMRI) analysis. However, HRF may vary from region to region and subject to subject. We investigated the effect of locally estimated HRF (in functionally homogenous parcels) on activation detection sensitivity in a heroin cue reactivity study.
Methods: We proposed a novel exploratory method for brain parcellation based on a probabilistic model to segregate the brain into spatially connected and functionally homogeneous components. Then, we estimated HRF and detected activated regions in response to an experimental task in each parcel using a joint detection estimation (JDE) method. We compared the proposed JDE method with the general linear model (GLM) that uses a fixed HRF and is implemented in FEAT (as a part of FMRIB Software Library, version 4.1).
Results: 1) Regions detected by JDE are larger than those detected by fixed HRF, 2) In group analysis, JDE found areas of activation not detected by fixed HRF. It detected drug craving a priori “regions-of-interest” in the limbic lobe (anterior cingulate cortex [ACC], posterior cingulate cortex [PCC] and cingulate gyrus), basal ganglia, especially striatum (putamen and
head of caudate), and cerebellum in addition to the areas detected by the fixed HRF method, 3) JDE obtained higher Z-values of local maxima compared to those obtained by fixed HRF.
Conclusion: In our study of heroin cue reactivity, our proposed method (that estimates HRF locally) outperformed the conventional GLM that uses a fixed HRF.
Journal title :
Basic and Clinical Neuroscience
Journal title :
Basic and Clinical Neuroscience