Title of article
Development of New Therapeutic Strategies in Gynecological Cancers in Iran by Utilizing Xenograft Model of Ovarian Adenocarcinoma
Author/Authors
Mazaheri، Zohreh نويسنده Anatomical Sciences Department, Faculty of Medical sciences, Tarbiat Modares University, Tehran, Iran. Mazaheri, Zohreh , Muhammadnejad، Samad نويسنده University of Tehran , , Muhammadnejad، Ahad نويسنده Tehran University of Medical Sciences , , Zargarzadeh، Moein نويسنده Reproductive Health Research Center, Tehran University of Medical Sciences, Tehran, Iran Zargarzadeh, Moein , Haghighi، Maryam نويسنده Student Research Committee, School of Nursing and Midwifery, Shiraz University of Medical Sciences, Shiraz, Iran , , Ali Oghabian، Mohammad نويسنده Research Center for Science and Technology in Medicine, Tehran University of Medical Sciences, Tehra Ali Oghabian, Mohammad , Tirgari، Farrokh نويسنده , , Amanpour، Saeid نويسنده Vali-e-Asr Reproductive Health Research Centre, Tehran University of Medical Sciences, Tehran, Iran. ,
Issue Information
فصلنامه با شماره پیاپی 0 سال 2010
Pages
3
From page
105
To page
107
Abstract
Objective: To evaluate the potentiality of OVCAR–3 cell line of ovarian adenocarcinoma as a xenograft model for ovarian adenocarcinoma in nude mice.
Materials and methods: The cell line isolated from advanced human ovarian adenocarcinoma, were inoculated to eight nude mice and two months later. Established tumors were transferred to pathology laboratory to be prepared by H&E staining and immunohistochemical staining with CA125 antibody.
Results: Study of H&E slides showed advanced adenocarcinoma. The CA125 Tumor marker was also positive in tumoral tissue.
Conclusion: Established tumors showed excellently the characteristics of ovarian adenocarcinoma. This model can be used to evaluate new treatment strategies.
Journal title
Journal of Family and Reproductive Health
Serial Year
2010
Journal title
Journal of Family and Reproductive Health
Record number
2394187
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