Title of article :
Development of New Therapeutic Strategies in Gynecological Cancers in Iran by Utilizing Xenograft Model of Ovarian Adenocarcinoma
Author/Authors :
Mazaheri، Zohreh نويسنده Anatomical Sciences Department, Faculty of Medical sciences, Tarbiat Modares University, Tehran, Iran. Mazaheri, Zohreh , Muhammadnejad، Samad نويسنده University of Tehran , , Muhammadnejad، Ahad نويسنده Tehran University of Medical Sciences , , Zargarzadeh، Moein نويسنده Reproductive Health Research Center, Tehran University of Medical Sciences, Tehran, Iran Zargarzadeh, Moein , Haghighi، Maryam نويسنده Student Research Committee, School of Nursing and Midwifery, Shiraz University of Medical Sciences, Shiraz, Iran , , Ali Oghabian، Mohammad نويسنده Research Center for Science and Technology in Medicine, Tehran University of Medical Sciences, Tehra Ali Oghabian, Mohammad , Tirgari، Farrokh نويسنده , , Amanpour، Saeid نويسنده Vali-e-Asr Reproductive Health Research Centre, Tehran University of Medical Sciences, Tehran, Iran. ,
Issue Information :
فصلنامه با شماره پیاپی 0 سال 2010
Pages :
3
From page :
105
To page :
107
Abstract :

Objective: To evaluate the potentiality of OVCAR–3 cell line of ovarian adenocarcinoma as a xenograft model for ovarian adenocarcinoma in nude mice.
Materials and methods: The cell line isolated from advanced human ovarian adenocarcinoma, were inoculated to eight nude mice and two months later. Established tumors were transferred to pathology laboratory to be prepared by H&E staining and immunohistochemical staining with CA125 antibody.
Results: Study of H&E slides showed advanced adenocarcinoma. The CA125 Tumor marker was also positive in tumoral tissue.
Conclusion: Established tumors showed excellently the characteristics of ovarian adenocarcinoma. This model can be used to evaluate new treatment strategies.

Journal title :
Journal of Family and Reproductive Health
Serial Year :
2010
Journal title :
Journal of Family and Reproductive Health
Record number :
2394187
Link To Document :
https://search.isc.ac/dl/search/defaultta.aspx?DTC=10&DC=2394187
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