Author/Authors :
Fesahat، Farzaneh نويسنده Research and Clinical Center for Infertility, Shahid Sadoughi University of Medical Sciences, Yazd, Iran , , Khoshneviszadeh، Mehdi نويسنده Department of Medicinal Chemistry, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran. , , Foroumadi، Alireza نويسنده , , Fereidounpour، Maryam نويسنده Faculty of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran. , , Sakhteman، Amirhossein نويسنده Department of Medicinal Chemistry, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran. ,
Abstract :
Some N-substituted piperidine structures were synthesized and evaluated for cytotoxicity. The N-substituted piperidine with propene substructure could be considered as a lead structure for further studies of structure activity relationship to develop more potent compounds in future. The compounds were evaluated against four different cell lines using the standard MTT assay method and doxorubicin was used as the reference drug. The IC50 values were determined by constructing dose-response curves and revealed that three of the synthesized compounds were active against breast cancer cell lines. Compound 6a bearing hydroxyl at para position of piperidine ring was the most active compound within this series.
