Author/Authors :
Dabbous، Hany M. نويسنده Ain Shams Center for Organ Transplant, Faculty of Medicine, Ain Shams University, Cairo, Egypt , , Montasser، Iman F. نويسنده Ain Shams Center for Organ Transplant, Faculty of Medicine, Ain Shams University, Cairo, Egypt , , Sakr، Mohamed A. نويسنده Ain Shams Center for Organ Transplant, Faculty of Medicine, Ain Shams University, Cairo, Egypt , , Refai، Rasha نويسنده Ain Shams Center for Organ Transplant, Faculty of Medicine, Ain Shams University, Cairo, Egypt , , Sayam، Moataz نويسنده Ain Shams Center for Organ Transplant, Faculty of Medicine, Ain Shams University, Cairo, Egypt , , Abdelmonem، Ahmed نويسنده Ain Shams Center for Organ Transplant, Faculty of Medicine, Ain Shams University, Cairo, Egypt , , Sayed، Hany نويسنده Ain Shams Center for Organ Transplant, Faculty of Medicine, Ain Shams University, Cairo, Egypt , , F. Abdelghafar، Mohamed نويسنده Ain Shams Center for Organ Transplant, Faculty of Medicine, Ain Shams University, Cairo, Egypt , , Bahaa، Mohamed نويسنده Ain Shams Center for Organ Transplant, Faculty of Medicine, Ain Shams University, Cairo, Egypt , , S. Elmeteini، Mahmoud نويسنده Ain Shams Center for Organ Transplant, Faculty of Medicine, Ain Shams University, Cairo, Egypt ,
Abstract :
Recurrence of HCV after living donor liver transplant (LDLT) is nearly universal, with almost one third of recipients developing cirrhosis and graft failure within 5 years after LDLT. Different studies have been published on the effect of sofosbuvir after liver transplantation on recurrent HCV with different genotypes. The aim of this study was to evaluate the efficacy, safety, and tolerability of sofosbuvir and ribavirin in LDLT recipients with recurrent HCV genotype 4. Thirty-nine Egyptian LDLT recipients were treated for recurrent HCV after LDLT with nucleos(t)ide analog NS5B polymerase inhibitor, sofosbuvir, and ribavirin without pegylated interferon for 6 months (November 2014 to June 2015) in this intention-to-treat analysis. One recipient died 1 week after starting the treatment, but the remaining 38 patients completed 24 weeks of treatment and were then followed for 12 weeks after end of treatment (EOT). The sustained virological response (SVR) at week 12 after EOT was achieved in 76% (29/38) of recipients. SVR was significantly higher in treatment-naïve patients and in recipients with a low stage of fibrosis. Only 2 (5%) recipients developed severe pancytopenia and acute kidney injury. We recommend initiating treatment as soon as possible after liver transplantation with newer combinations, such as ledipasvir/sofosbuvir or sofosbuvir/simeprevir, rather than sofosbuvir with Ribavirin, to achieve higher rates of SVR.
