Author/Authors :
Beigmohammadi، Mohammad Taghi نويسنده Department of Anesthesiology and Critical Care, Imam
Khomeini Hospital Complex, Tehran University of medical Sciences,
Tehran, Iran , , Hussain Khan، Zahid نويسنده Department of Anesthesiology and Intensive Care Imam Khomeini Medical Center, Tehran University of Medical Sciences , , Samadi، Shahram نويسنده Department of Anesthesiology, Tehran University of Medical Sciences, Tehran, Iran. Samadi, Shahram , Mahmoodpoor، Ata نويسنده General ICU, Shohada Hospital, El-Goli St., Tabriz , , Fotouhi، Akbar نويسنده , , Rahimiforoushani، Abbas نويسنده Department of Epidemiology and Statistics, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran , , Asadi Gharabaghi، Mehrnaz نويسنده Division of Respiratory Disease, Department of Internal Medicine, Imam Khomeini Hospital Complex, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran ,
Abstract :
Hematocrit (Hct) is an important parameter for optimal oxygenation during discontinuation from ventilator, but there is no consensus about its concentration and effectiveness on successful extubation. The current study aimed to determine the role of Hct concentration on extubation failure in critically ill patients. The current prospective cohort study investigated the effect of age, gender and Hct level on successful extubation of 163 mechanically ventilated patients in Imam Khomeini hospital intensive care units (ICUs), Tehran, Iran. Following successful weaning process, the patients were classified into two groups on the basis of Hct level; 62 with an Hct level of 21% - 27% and the other 101 patients with Hct levels above 27%. The data were analyzed by chi-square test and multiple logistic regressions. A probability value of less than 0.05 was considered significant. There was no significant association between the level of Hct concentration and extubation failure (8.9% vs. 9.2%, P = 0.507). Gender and age were significantly associated with extubation failure (OR = 9.1, P = 0.034, OR = 12.5, P = 0.014, respectively). Although the differences between, before and after extubation of PaO2 and P/F ratio, were of significant values between the two different groups of Hct (P = 0.001, P = 0.004 respectively), they had no effect on the failure of extubation (P= 0.259, P = 0.403, respectively). Although some studies showed association between anemia and extubation failure, the current study could not confirm it. The study showed that males, regardless of the Hct level, had a better extubation success rate than those of females.
